Cardarine (GW501516) is a PPAR (Peroxisome proliferator-activated receptor) drug, which is also sold and marketed as a SARM (selective androgen receptor modulator). This drug started being researched in the early 1990’s by GlaxoSmithKline and Ligand Pharmaceuticals to treat diabetes, obesity, and heart disease.
As development went on, researchers started to notice that Cardarine (GW501516) was very effective at both fat loss and endurance. Because of this, many in the fitness community including sports athletes, bodybuilders, and those looking to lose fat grew its popularity. The rapid rise in usage started after the 2008 Chinese Olympics when many competitors used it to dope. At that time, it was not on the list of banned substances, but afterward, it was quickly added.
There were rumors that it was so effective that drug companies did not want the general public using it, as this would rob them of selling drugs that treated diseases. Whatever the actual reasons, Ligand pulled further research.
How it works
Cardarine (GW501516) works by binding very effectively to the sensors that detect steroidal hormones and thyroid receptors, causing the PGC-1a enzyme to become activated. This leads to a change in gene expression and altering of energy expenditure. In simple terms, this drug is essentially ‘exercise in a bottle’.
Rodent studies have shown Cardarine (GW501516) caused an increase in fatty acid metabolism. We also saw subjects reverse type 2 diabetes and reduce obesity, even when eating a poor diet. Finally, good cholesterol rose and bad cholesterol dropped in simian studies, even with little exercise.
There was also a human study done in Australia for 6 months where middle-aged men used Cardarine (GW501516) and kept their training and diet the same. They experienced a loss in body fat and a rise in endurance.
It is important to note that Cardarine (GW501516) is NOT a stimulant at all. Your heart rate while using it will actually drop during exercise, relative to where it would be in normal circumstances, so you can push harder for longer without getting winded. Stimulants meanwhile, will cause your heart rate to rise rapidly during your workout, causing you to tire out faster.
Those who have been lucky enough to use good quality Cardarine (GW501516) report some amazing results.
- Runners reported a drop in the race times. For example, I personally had my 5K time drop 30-45 seconds after 2 weeks on the drug.
- Weightlifters said they felt like they could go on forever in the gym, they simply did not get tired and did not experience a crash.
- Those seeking to lose body fat said they were able to keep their diet the same and still lose body fat after 6-8 weeks on the drug.
- Anabolic steroid users said that it helped offset negative side effects, especially from harsher compounds.
Cardarine (GW501516) also will not cause catabolic issues in the body. Meaning you can burn fat while still keeping your muscle. This gives it a huge advantage over other fat burning drugs like T3 Cytomel or Clenbuterol.
How to use
Cardarine (GW501516) can be run solo if you simply want fat loss and endurance boost.
In this scenario, I recommend using 20mg per day, and you can do 1 dose per day or 2 doses per day. For endurance run the drug 4-12 weeks. For fat loss, you must use it 8-12 weeks. I have found the endurance benefits start around week 2-3, while the fat loss starts to kick in around weeks 4-5.
Cardarine (GW501516) can also be used as part of a SARM’s (selective androgen receptor modulator) stack. In fact, I recommend you always use it as the base for your cycles. A simple dosage of 10-20mg per day will make your cycle twice as good.
For fat loss
Cardarine (GW501516) at 20mg per day + S4 Andarine 50mg per day + LGD 4033 Ligandrol Anabolicum 10mg per day.
For endurance boost
Cardarine (GW501516) at 20mg per day + SR9009 Stenabolic at 20mg per day (splitting the dosage 2-3X per day or pre-workout)
Stacking With Anabolic Steroids
You should also consider stacking it with an anabolic steroid cycle too. Users say that stacking Cardarine (GW501516) with Trenbolone (finaplix) helps offset the negative side effects. If you are doing a cutting stack, with Equipoise or Primobolan for example, adding in Cardarine (GW501516) will speed up fat loss while eating in a calorie deficit.
Post cycle therapy
It is perfectly safe to use it during your post cycle therapy, bridge, or off cycle. Please see the Perfect PCT protocol at evolutionary.org.
Cardarine (GW501516) is non-androgenic, non-estrogenic, and non-suppressive. The side effects are simply not existent. There has been some chatter about it causing cancer growth, but those have been proven to be false. In fact, Cardarine (GW501516) was found in studies to suppress cancer!
Even though it has minimal side effects I still recommend cycling off after 12 weeks for 4-8 weeks. Remember, you should cycle off all compounds to give your body a break.
Where to buy Cardarine
Cardarine (GW501516) became very popular over the past 5 years, and many research chemical companies started popping up selling it, including sites like eBay or Amazon. However, due to a government and financial crackdown in the United States, those sites have rapidly disappeared and it is becoming more difficult to find any legitimate product domestically. In fact, I can say with certainty that any domestic website selling it is likely selling you bunk product from China, a prohormone, or clenbuterol to trick you.
Luckily, you can still purchase real Cardarine (GW501516) from sarms1.com.
- Lohakare, J., Osorio, J., & Bionaz, M. (2018). Peroxisome proliferator-activated receptor β/δ does not regulate glucose uptake and lactose synthesis in bovine mammary epithelial cells cultivated in vitro. Journal of Dairy Research, 1-8. doi:10.1017/S0022029918000365
- Exercise Pills: At the Starting Line, Li, Shunchang et al., Trends in Pharmacological Sciences , Volume 36 , Issue 12 , 906 – 917
- Dimopoulos N, Watson M, Green C, Hundal HS: The PPARdelta agonist, GW501516, promotes fatty acid oxidation but has no direct effect on glucose utilisation or insulin sensitivity in rat L6 skeletal muscle cells. FEBS Lett. 2007 Oct 2;581(24):4743-8. Epub 2007 Sep 6. [PubMed:17869249]